RBBP8 protein (Canis lupus familiaris) - STRING interaction network

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Score

RBBP8

RB binding protein 8, endonuclease. (909 aa)

Predicted Functional Partners:

BRCA1

0.999

BARD1

0.993

CTBP1

0.986

MRE11

0.983

RAD50

0.983

CTBP2

0.982

NBN

0.967

EXO1

0.925

BRCA2

0.882

PALB2

0.878

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BRCA1	ENSCAFP00000021054	ENSCAFP00000048759	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	BRCA2	ENSCAFP00000021054	ENSCAFP00000009557	BRCA1 associated RING domain 1.	BRCA2 DNA repair associated.	0.953
BARD1	CTBP1	ENSCAFP00000021054	ENSCAFP00000024542	BRCA1 associated RING domain 1.	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.455
BARD1	EXO1	ENSCAFP00000021054	ENSCAFP00000023179	BRCA1 associated RING domain 1.	Exonuclease 1.	0.801
BARD1	MRE11	ENSCAFP00000021054	ENSCAFP00000006193	BRCA1 associated RING domain 1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.985
BARD1	NBN	ENSCAFP00000021054	ENSCAFP00000037607	BRCA1 associated RING domain 1.	Nibrin.	0.975
BARD1	PALB2	ENSCAFP00000021054	ENSCAFP00000037206	BRCA1 associated RING domain 1.	Partner and localizer of BRCA2.	0.951
BARD1	RAD50	ENSCAFP00000021054	ENSCAFP00000040203	BRCA1 associated RING domain 1.	RAD50 double strand break repair protein.	0.944
BARD1	RBBP8	ENSCAFP00000021054	ENSCAFP00000026919	BRCA1 associated RING domain 1.	RB binding protein 8, endonuclease.	0.993
BRCA1	BARD1	ENSCAFP00000048759	ENSCAFP00000021054	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated RING domain 1.	0.999
BRCA1	BRCA2	ENSCAFP00000048759	ENSCAFP00000009557	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA2 DNA repair associated.	0.999
BRCA1	CTBP1	ENSCAFP00000048759	ENSCAFP00000024542	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.413
BRCA1	EXO1	ENSCAFP00000048759	ENSCAFP00000023179	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Exonuclease 1.	0.845
BRCA1	MRE11	ENSCAFP00000048759	ENSCAFP00000006193	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.973
BRCA1	NBN	ENSCAFP00000048759	ENSCAFP00000037607	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Nibrin.	0.828
BRCA1	PALB2	ENSCAFP00000048759	ENSCAFP00000037206	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Partner and localizer of BRCA2.	0.999
BRCA1	RAD50	ENSCAFP00000048759	ENSCAFP00000040203	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RAD50 double strand break repair protein.	0.861
BRCA1	RBBP8	ENSCAFP00000048759	ENSCAFP00000026919	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RB binding protein 8, endonuclease.	0.999
BRCA2	BARD1	ENSCAFP00000009557	ENSCAFP00000021054	BRCA2 DNA repair associated.	BRCA1 associated RING domain 1.	0.953
BRCA2	BRCA1	ENSCAFP00000009557	ENSCAFP00000048759	BRCA2 DNA repair associated.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999