STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)    
Predicted Functional Partners:
YTHDF1
YTH N6-methyladenosine RNA binding protein 1.
   
  
 0.888
METTL14
Methyltransferase like 14; Belongs to the MT-A70-like family.
   
  
 0.878
YTHDF3
YTH N6-methyladenosine RNA binding protein 3.
   
  
 0.876
FTO
Alpha-ketoglutarate-dependent dioxygenase FTO; RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating th [...]
   
  
 0.868
YTHDF2
YTH N6-methyladenosine RNA binding protein 2.
      
 0.854
WTAP
WT1 associated protein.
   
  
 0.835
METTL3
Methyltransferase like 3; Belongs to the MT-A70-like family.
   
  
 0.816
YTHDC2
YTH domain containing 2.
     
 0.815
ZC3H13
Zinc finger CCCH-type containing 13.
      
 0.805
RBM15
RNA binding motif protein 15.
   
  
 0.719
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.