TYMS protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

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Score

TYMS

Thymidylate synthetase. (314 aa)

Predicted Functional Partners:

DHFR

0.996

TK1

0.995

SHMT1

0.986

SHMT2

0.985

FPGS

0.973

MTHFD2

0.972

MTHFD2L

0.972

LOC609048

0.971

DCTD

0.970

MTHFR

0.961

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCTD	TK1	ENSCAFP00000041962	ENSCAFP00000007911	dCMP deaminase.	Thymidine kinase.	0.986
DCTD	TYMS	ENSCAFP00000041962	ENSCAFP00000027096	dCMP deaminase.	Thymidylate synthetase.	0.970
DHFR	FPGS	ENSCAFP00000036312	ENSCAFP00000029808	DHFR domain-containing protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.987
DHFR	MTHFR	ENSCAFP00000036312	ENSCAFP00000060565	DHFR domain-containing protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.550
DHFR	SHMT1	ENSCAFP00000036312	ENSCAFP00000026966	DHFR domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.975
DHFR	SHMT2	ENSCAFP00000036312	ENSCAFP00000000282	DHFR domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.976
DHFR	TK1	ENSCAFP00000036312	ENSCAFP00000007911	DHFR domain-containing protein.	Thymidine kinase.	0.638
DHFR	TYMS	ENSCAFP00000036312	ENSCAFP00000027096	DHFR domain-containing protein.	Thymidylate synthetase.	0.996
FPGS	DHFR	ENSCAFP00000029808	ENSCAFP00000036312	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	DHFR domain-containing protein.	0.987
FPGS	LOC609048	ENSCAFP00000029808	ENSCAFP00000038964	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.878
FPGS	MTHFD2	ENSCAFP00000029808	ENSCAFP00000012812	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Uncharacterized protein.	0.863
FPGS	MTHFD2L	ENSCAFP00000029808	ENSCAFP00000059857	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.862
FPGS	MTHFR	ENSCAFP00000029808	ENSCAFP00000060565	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.612
FPGS	SHMT1	ENSCAFP00000029808	ENSCAFP00000026966	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.909
FPGS	SHMT2	ENSCAFP00000029808	ENSCAFP00000000282	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.909
FPGS	TK1	ENSCAFP00000029808	ENSCAFP00000007911	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Thymidine kinase.	0.474
FPGS	TYMS	ENSCAFP00000029808	ENSCAFP00000027096	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Thymidylate synthetase.	0.973
LOC609048	FPGS	ENSCAFP00000038964	ENSCAFP00000029808	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.878
LOC609048	MTHFR	ENSCAFP00000038964	ENSCAFP00000060565	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.521
LOC609048	SHMT1	ENSCAFP00000038964	ENSCAFP00000026966	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.781