STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PGRMC1Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. (195 aa)    
Predicted Functional Partners:
CYP51A1
Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.
   
 
 0.643
PGR
Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily.
      
 0.643
TMEM97
Transmembrane protein 97.
   
  
 0.631
UBE4A
Ubiquitination factor E4A.
    
 
 0.584
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
   
 
 0.579
CYB5A
Cytochrome b5A microsomal variant; Belongs to the cytochrome b5 family.
   
  
 0.568
PAQR8
Progestin and adipoQ receptor family member 8.
    
 
 0.520
PAQR7
Progestin and adipoQ receptor family member 7.
    
 
 0.489
DNAJB6
DnaJ heat shock protein family (Hsp40) member B6.
   
 
 0.478
SIGMAR1
Sigma non-opioid intracellular receptor 1.
   
  
 0.464
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.