ISL1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

ISL1

ISL LIM homeobox 1. (370 aa)

Predicted Functional Partners:

LHX3

0.768

NKX2-5

0.758

LDB1

0.749

TBX18

0.712

ATOH7

0.710

PITX2

0.695

PAX4

0.686

LDB2

0.679

TBX5

0.654

BARHL2

0.653

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH7	ISL1	ENSCAFP00000019963	ENSCAFP00000027248	Atonal bHLH transcription factor 7.	ISL LIM homeobox 1.	0.710
BARHL2	ISL1	ENSCAFP00000029951	ENSCAFP00000027248	BarH like homeobox 2.	ISL LIM homeobox 1.	0.653
ISL1	ATOH7	ENSCAFP00000027248	ENSCAFP00000019963	ISL LIM homeobox 1.	Atonal bHLH transcription factor 7.	0.710
ISL1	BARHL2	ENSCAFP00000027248	ENSCAFP00000029951	ISL LIM homeobox 1.	BarH like homeobox 2.	0.653
ISL1	LDB1	ENSCAFP00000027248	ENSCAFP00000014734	ISL LIM homeobox 1.	LIM domain binding 1.	0.749
ISL1	LDB2	ENSCAFP00000027248	ENSCAFP00000046020	ISL LIM homeobox 1.	LIM domain binding 2.	0.679
ISL1	LHX3	ENSCAFP00000027248	ENSCAFP00000018765	ISL LIM homeobox 1.	LIM homeobox 3.	0.768
ISL1	NKX2-5	ENSCAFP00000027248	ENSCAFP00000041395	ISL LIM homeobox 1.	Transcription factor NKX2.5.	0.758
ISL1	PAX4	ENSCAFP00000027248	ENSCAFP00000002500	ISL LIM homeobox 1.	Paired box 4.	0.686
ISL1	PITX2	ENSCAFP00000027248	ENSCAFP00000059724	ISL LIM homeobox 1.	Paired like homeodomain 2.	0.695
ISL1	TBX18	ENSCAFP00000027248	ENSCAFP00000055663	ISL LIM homeobox 1.	T-box transcription factor 18.	0.712
ISL1	TBX5	ENSCAFP00000027248	ENSCAFP00000013523	ISL LIM homeobox 1.	T-box transcription factor 5.	0.654
LDB1	ISL1	ENSCAFP00000014734	ENSCAFP00000027248	LIM domain binding 1.	ISL LIM homeobox 1.	0.749
LDB1	LHX3	ENSCAFP00000014734	ENSCAFP00000018765	LIM domain binding 1.	LIM homeobox 3.	0.802
LDB2	ISL1	ENSCAFP00000046020	ENSCAFP00000027248	LIM domain binding 2.	ISL LIM homeobox 1.	0.679
LDB2	LHX3	ENSCAFP00000046020	ENSCAFP00000018765	LIM domain binding 2.	LIM homeobox 3.	0.764
LHX3	ISL1	ENSCAFP00000018765	ENSCAFP00000027248	LIM homeobox 3.	ISL LIM homeobox 1.	0.768
LHX3	LDB1	ENSCAFP00000018765	ENSCAFP00000014734	LIM homeobox 3.	LIM domain binding 1.	0.802
LHX3	LDB2	ENSCAFP00000018765	ENSCAFP00000046020	LIM homeobox 3.	LIM domain binding 2.	0.764
LHX3	PITX2	ENSCAFP00000018765	ENSCAFP00000059724	LIM homeobox 3.	Paired like homeodomain 2.	0.558

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

14

PPI enrichment p-value:

1.87e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030216

Keratinocyte differentiation

4 of 69

2.03

1.79

0.00028

GO:0043588

Skin development

5 of 156

1.77

1.76

0.00015

GO:0006672

Ceramide metabolic process

4 of 86

1.93

1.66

0.00043

GO:0031424

Keratinization

3 of 28

2.29

1.57

0.0011

GO:0046513

Ceramide biosynthetic process

3 of 51

2.03

1.29

0.0032

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28815464

(2018) Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment.

8 of 12

3.09

9.46

1.74e-18

PMID:31833240

(2020) Targeted regions sequencing identified four novel PNPLA1 mutations in two Chinese families with autosomal recessive congenital ichthyosis.

8 of 26

2.75

8.13

1.25e-16

PMID:28249031

(2017) A de novo variant in the ASPRV1 gene in a dog with ichthyosis.

6 of 11

3.0

6.41

1.16e-12

PMID:28122049

(2017) A Defect in NIPAL4 Is Associated with Autosomal Recessive Congenital Ichthyosis in American Bulldogs.

6 of 12

2.96

6.36

1.30e-12

PMID:34599683

(2021) A frameshift insertion in FA2H causes a recessively inherited form of ichthyosis congenita in Chianina cattle.

5 of 8

3.06

5.22

2.44e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:33340

Mixed, incl. Magnesium ion transmembrane transport, and Keratinization

7 of 10

3.11

8.57

1.06e-16

CL:33344

Mixed, incl. Keratinization, and Apolipoprotein A-I receptor binding

5 of 5

3.26

6.13

6.22e-12

CL:13676

Mixed, incl. Winged helix Storkhead-box1 domain, and Hemimethylated DNA-binding protein YccV like

2 of 6

2.79

1.33

0.0038

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