STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (901 aa)    
Predicted Functional Partners:
HCN3
Hyperpolarization activated cyclic nucleotide gated potassium channel 3.
  
 
0.917
HCN2
Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2.
  
  
0.904
KCNJ2
Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...]
   
  
 0.576
TBX5
T-box transcription factor 5.
   
  
 0.573
HCN4
Hyperpolarization activated cyclic nucleotide gated potassium channel 4.
  
  
0.511
SYT1
Synaptotagmin 1.
      
 0.478
SYT2
Synaptotagmin 2.
      
 0.478
ATP2B3
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
   
  
 0.461
ASTN1
Astrotactin 1.
      
 0.454
MYL2
Myosin light chain 2.
   
  
 0.420
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.