STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LAMA1Laminin subunit alpha 1. (3034 aa)    
Predicted Functional Partners:
DAG1
Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]
   
 0.925
LAMA2
Laminin subunit alpha 2.
  
 
0.922
ITGA2
Integrin subunit alpha 2; Belongs to the integrin alpha chain family.
   
 0.825
ITGA10
Integrin subunit alpha 10; Belongs to the integrin alpha chain family.
   
 0.821
ITGA7
Integrin subunit alpha 7; Belongs to the integrin alpha chain family.
    
 0.802
ITGB3
Integrin beta; Belongs to the integrin beta chain family.
    
 0.800
ITGA11
Integrin subunit alpha 11; Belongs to the integrin alpha chain family.
    
 0.798
PELO
Integrin subunit alpha 1; Belongs to the integrin alpha chain family.
    
 0.797
ITGA2B
Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.
   
 0.789
ITGB4
Integrin beta.
   
 0.784
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.