STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WSB1WD repeat and SOCS box containing 1. (421 aa)    
Predicted Functional Partners:
CUL5
Cullin 5; Belongs to the cullin family.
   
 0.766
SPSB2
SplA/ryanodine receptor domain and SOCS box containing 2.
     
 0.696
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
   
 
 0.653
KANSL2
KAT8 regulatory NSL complex subunit 2.
    
 
 0.648
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
   
 
0.648
ELOB
Elongin B.
    
 0.630
ANKRD37
Ankyrin repeat domain 37.
   
 
 0.624
RBX1
Ring-box 1.
    
 0.618
VHL
Von Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity).
   
 0.603
ELOC
Elongin C; Belongs to the SKP1 family.
   
 0.603
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.