STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NRTNNeurturin. (195 aa)    
Predicted Functional Partners:
GFRA2
GDNF family receptor alpha 2.
    
 0.994
RET
Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.955
GFRA1
GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family.
    
 0.870
PSPN
Persephin.
  
 
0.822
NGF
Nerve growth factor; Belongs to the NGF-beta family.
   
  
 0.805
SDC3
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
   
  
 0.803
GFRA3
GDNF family receptor alpha 3.
    
 
 0.794
CDNF
Cerebral dopamine neurotrophic factor.
      
 0.791
GDNF
Glial cell derived neurotrophic factor.
   
 
0.714
TH
Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.
   
  
 0.688
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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