STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPR3Natriuretic peptide receptor 3. (497 aa)    
Predicted Functional Partners:
NPPA
Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.
   
 
 0.963
NPPC
Natriuretic peptide C.
   
 
 0.897
APLP1
Amyloid beta precursor like protein 1.
      
 0.695
HSD17B2
Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.687
TRHR
Thyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.683
EGLN3
Egl-9 family hypoxia inducible factor 3.
      
 0.618
KCNJ5
Potassium voltage-gated channel subfamily J member 5.
      
 0.594
RAB12
Uncharacterized protein.
      
 0.565
SEMA3A
Semaphorin 3A; Belongs to the semaphorin family.
    
 
 0.510
GAD2
Glutamate decarboxylase 2; Catalyzes the production of GABA.
      
 0.486
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.