BRS3 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BRS3

Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family. (399 aa)

Predicted Functional Partners:

NMB

0.966

GRP

0.949

GRPR

0.910

NMBR

0.907

GPD1L

0.806

SCN3B

0.781

ANKRD55

0.754

SCN1B

0.728

NTS

0.715

KCNJ8

0.701

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD55	BRS3	ENSCAFP00000010278	ENSCAFP00000027963	Ankyrin repeat domain 55.	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	0.754
BRS3	ANKRD55	ENSCAFP00000027963	ENSCAFP00000010278	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Ankyrin repeat domain 55.	0.754
BRS3	GPD1L	ENSCAFP00000027963	ENSCAFP00000056077	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Glycerol-3-phosphate dehydrogenase [NAD(+)].	0.806
BRS3	GRP	ENSCAFP00000027963	ENSCAFP00000000137	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.	0.949
BRS3	GRPR	ENSCAFP00000027963	ENSCAFP00000018079	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Gastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family.	0.910
BRS3	KCNJ8	ENSCAFP00000027963	ENSCAFP00000036689	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Potassium voltage-gated channel subfamily J member 8.	0.701
BRS3	NMB	ENSCAFP00000027963	ENSCAFP00000036677	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Neuromedin B.	0.966
BRS3	NMBR	ENSCAFP00000027963	ENSCAFP00000000410	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Neuromedin B receptor; Belongs to the G-protein coupled receptor 1 family.	0.907
BRS3	NTS	ENSCAFP00000027963	ENSCAFP00000008959	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.	0.715
BRS3	SCN1B	ENSCAFP00000027963	ENSCAFP00000010590	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.	0.728
BRS3	SCN3B	ENSCAFP00000027963	ENSCAFP00000057747	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	Sodium voltage-gated channel beta subunit 3.	0.781
GPD1L	BRS3	ENSCAFP00000056077	ENSCAFP00000027963	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	0.806
GPD1L	KCNJ8	ENSCAFP00000056077	ENSCAFP00000036689	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Potassium voltage-gated channel subfamily J member 8.	0.788
GPD1L	SCN1B	ENSCAFP00000056077	ENSCAFP00000010590	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.	0.827
GPD1L	SCN3B	ENSCAFP00000056077	ENSCAFP00000057747	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Sodium voltage-gated channel beta subunit 3.	0.818
GRP	BRS3	ENSCAFP00000000137	ENSCAFP00000027963	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	0.949
GRP	GRPR	ENSCAFP00000000137	ENSCAFP00000018079	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.	Gastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family.	0.994
GRP	NMB	ENSCAFP00000000137	ENSCAFP00000036677	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.	Neuromedin B.	0.973
GRP	NMBR	ENSCAFP00000000137	ENSCAFP00000000410	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.	Neuromedin B receptor; Belongs to the G-protein coupled receptor 1 family.	0.920
GRP	NTS	ENSCAFP00000000137	ENSCAFP00000008959	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.	Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.	0.854