Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VPS53VPS53 subunit of GARP complex. (832 aa)    
Predicted Functional Partners:
VPS51
VPS51 subunit of GARP complex.
   
 0.999
VPS52
Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...]
   
 0.996
VPS54
VPS54 subunit of GARP complex.
   
 0.993
ENSCAFP00000056162
Uncharacterized protein.
   
 0.990
EIPR1
EARP complex and GARP complex interacting protein 1.
    
 0.984
VPS50
VPS50 subunit of EARP/GARPII complex.
   
 0.979
AFAP1L1
Actin filament associated protein 1 like 1.
      
 0.897
GEMIN4
Gem nuclear organelle associated protein 4.
      
 0.891
RPH3AL
Rabphilin 3A like (without C2 domains).
      
 0.885
COG4
Component of oligomeric golgi complex 4.
   
  
 0.851
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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