STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRKCRK proto-oncogene, adaptor protein. (385 aa)    
Predicted Functional Partners:
ABL1
Tyrosine-protein kinase.
    
0.994
BCAR1
BCAR1 scaffold protein, Cas family member.
    
 0.991
CBL
Cbl proto-oncogene.
    
 0.986
RAPGEF1
Rap guanine nucleotide exchange factor 1.
    
 0.984
PTK2
Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.981
SRC
Tyrosine-protein kinase.
   
 0.980
ABL2
Tyrosine-protein kinase.
    
0.974
GAB1
GRB2 associated binding protein 1.
    
 0.972
EGFR
Receptor protein-tyrosine kinase.
    
 0.971
FRS2
Fibroblast growth factor receptor substrate 2.
   
 0.969
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.