MATK protein (Canis lupus familiaris) - STRING interaction network

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Score

MATK

Tyrosine-protein kinase. (507 aa)

Predicted Functional Partners:

NTRK3

0.903

NTRK2

0.903

PAG1

0.736

EGFR

0.709

COX1

0.688

SRC

0.662

YES1

0.652

ERBB3

0.610

ERBB2

0.610

ERBB4

0.610

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COX1	MATK	ENSCAFP00000030311	ENSCAFP00000028300	Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]	Tyrosine-protein kinase.	0.688
EGFR	ERBB2	ENSCAFP00000005164	ENSCAFP00000024079	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.997
EGFR	ERBB3	ENSCAFP00000005164	ENSCAFP00000000139	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.979
EGFR	ERBB4	ENSCAFP00000005164	ENSCAFP00000048210	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.888
EGFR	MATK	ENSCAFP00000005164	ENSCAFP00000028300	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.709
EGFR	NTRK2	ENSCAFP00000005164	ENSCAFP00000063233	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.485
EGFR	PAG1	ENSCAFP00000005164	ENSCAFP00000012389	Receptor protein-tyrosine kinase.	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.540
EGFR	SRC	ENSCAFP00000005164	ENSCAFP00000044994	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.989
EGFR	YES1	ENSCAFP00000005164	ENSCAFP00000063973	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components su [...]	0.720
ERBB2	EGFR	ENSCAFP00000024079	ENSCAFP00000005164	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Receptor protein-tyrosine kinase.	0.997
ERBB2	ERBB3	ENSCAFP00000024079	ENSCAFP00000000139	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Erb-b2 receptor tyrosine kinase 3.	0.998
ERBB2	ERBB4	ENSCAFP00000024079	ENSCAFP00000048210	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Receptor protein-tyrosine kinase.	0.991
ERBB2	MATK	ENSCAFP00000024079	ENSCAFP00000028300	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase.	0.610
ERBB2	NTRK2	ENSCAFP00000024079	ENSCAFP00000063233	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase receptor.	0.442
ERBB2	SRC	ENSCAFP00000024079	ENSCAFP00000044994	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase.	0.964
ERBB2	YES1	ENSCAFP00000024079	ENSCAFP00000063973	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components su [...]	0.622
ERBB3	EGFR	ENSCAFP00000000139	ENSCAFP00000005164	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.979
ERBB3	ERBB2	ENSCAFP00000000139	ENSCAFP00000024079	Erb-b2 receptor tyrosine kinase 3.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.998
ERBB3	ERBB4	ENSCAFP00000000139	ENSCAFP00000048210	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.970
ERBB3	MATK	ENSCAFP00000000139	ENSCAFP00000028300	Erb-b2 receptor tyrosine kinase 3.	Tyrosine-protein kinase.	0.610