STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HMOX2Heme oxygenase 2. (316 aa)    
Predicted Functional Partners:
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
  
 
 0.975
BLVRA
Biliverdin reductase A.
   
 
 0.957
FXN
Frataxin.
   
 
 0.931
HCCS
Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.
     
 0.928
HEPH
Hephaestin; Belongs to the multicopper oxidase family.
    
 0.924
COX10
Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10.
   
 
 0.918
LOC611632
Uncharacterized protein; Belongs to the multicopper oxidase family.
    
 0.912
CP
Ceruloplasmin; Belongs to the multicopper oxidase family.
    
 0.912
HMOX1
Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.
  
 
0.908
CPOX
Coproporphyrinogen oxidase.
      
 0.786
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.