STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NCLNNicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. (563 aa)    
Predicted Functional Partners:
CCDC47
Coiled-coil domain containing 47.
   
 
 0.963
TMEM147
Transmembrane protein 147.
   
 
 0.957
TMCO1
Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling; Belongs to the TMCO1 family.
   
 
 0.932
SEC61A2
Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC [...]
   
 
 0.922
SDR39U1
Short chain dehydrogenase/reductase family 39U member 1.
   
  
 0.895
SMPD4
Sphingomyelin phosphodiesterase 4.
   
  
 0.852
RPL15
60S ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family.
   
 
 0.831
RPL19
60S ribosomal protein L19.
    
   0.823
RPL27A
Ribosomal_L18e/L15P domain-containing protein; Belongs to the universal ribosomal protein uL15 family.
    
 
 0.822
ENSCAFP00000040194
annotation not available
    
 
 0.822
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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