TLE2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TLE2

TLE family member 2, transcriptional corepressor. (743 aa)

Predicted Functional Partners:

LEF1

0.740

TCF7L1

0.690

GNA15

0.690

TCF7L2

0.690

TCF7

0.690

TLE1

0.641

HDAC1

0.616

HES4

0.610

PYGO1

0.588

EP300

0.558

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EP300	HDAC1	ENSCAFP00000001585	ENSCAFP00000036819	E1A binding protein p300.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.836
EP300	LEF1	ENSCAFP00000001585	ENSCAFP00000056485	E1A binding protein p300.	Lymphoid enhancer binding factor 1.	0.718
EP300	TCF7	ENSCAFP00000001585	ENSCAFP00000043629	E1A binding protein p300.	Transcription factor 7.	0.930
EP300	TCF7L1	ENSCAFP00000001585	ENSCAFP00000011603	E1A binding protein p300.	Transcription factor 7 like 1.	0.925
EP300	TCF7L2	ENSCAFP00000001585	ENSCAFP00000039879	E1A binding protein p300.	Transcription factor 7 like 2.	0.930
EP300	TLE1	ENSCAFP00000001585	ENSCAFP00000002118	E1A binding protein p300.	TLE family member 1, transcriptional corepressor.	0.549
EP300	TLE2	ENSCAFP00000001585	ENSCAFP00000028496	E1A binding protein p300.	TLE family member 2, transcriptional corepressor.	0.558
GNA15	TLE2	ENSCAFP00000028444	ENSCAFP00000028496	G protein subunit alpha 15.	TLE family member 2, transcriptional corepressor.	0.690
HDAC1	EP300	ENSCAFP00000036819	ENSCAFP00000001585	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	E1A binding protein p300.	0.836
HDAC1	LEF1	ENSCAFP00000036819	ENSCAFP00000056485	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Lymphoid enhancer binding factor 1.	0.760
HDAC1	PYGO1	ENSCAFP00000036819	ENSCAFP00000023436	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Pygopus family PHD finger 1.	0.543
HDAC1	TCF7	ENSCAFP00000036819	ENSCAFP00000043629	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Transcription factor 7.	0.588
HDAC1	TCF7L1	ENSCAFP00000036819	ENSCAFP00000011603	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Transcription factor 7 like 1.	0.595
HDAC1	TCF7L2	ENSCAFP00000036819	ENSCAFP00000039879	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Transcription factor 7 like 2.	0.647
HDAC1	TLE1	ENSCAFP00000036819	ENSCAFP00000002118	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	TLE family member 1, transcriptional corepressor.	0.862
HDAC1	TLE2	ENSCAFP00000036819	ENSCAFP00000028496	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	TLE family member 2, transcriptional corepressor.	0.616
HES4	TLE1	ENSCAFP00000037009	ENSCAFP00000002118	Hes family bHLH transcription factor 4.	TLE family member 1, transcriptional corepressor.	0.610
HES4	TLE2	ENSCAFP00000037009	ENSCAFP00000028496	Hes family bHLH transcription factor 4.	TLE family member 2, transcriptional corepressor.	0.610
LEF1	EP300	ENSCAFP00000056485	ENSCAFP00000001585	Lymphoid enhancer binding factor 1.	E1A binding protein p300.	0.718
LEF1	HDAC1	ENSCAFP00000056485	ENSCAFP00000036819	Lymphoid enhancer binding factor 1.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.760