RNF151 protein (Canis lupus familiaris) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Score

RNF151

Ring finger protein 151. (244 aa)

Predicted Functional Partners:

RNF175

0.670

PAMR1

0.633

RNF126

0.597

RNF122

0.548

BIRC6

0.536

CMTR1

0.522

POLR3F

0.522

SPATA19

0.515

NSMCE1

0.515

TEKT3

0.515

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC6	RNF151	ENSCAFP00000008679	ENSCAFP00000028784	Baculoviral IAP repeat containing 6.	Ring finger protein 151.	0.536
CMTR1	POLR3F	ENSCAFP00000002124	ENSCAFP00000008061	Cap methyltransferase 1.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.480
CMTR1	RNF151	ENSCAFP00000002124	ENSCAFP00000028784	Cap methyltransferase 1.	Ring finger protein 151.	0.522
NSMCE1	RNF151	ENSCAFP00000025739	ENSCAFP00000028784	NSE1 homolog, SMC5-SMC6 complex component.	Ring finger protein 151.	0.515
PAMR1	RNF151	ENSCAFP00000060491	ENSCAFP00000028784	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	Ring finger protein 151.	0.633
POLR3F	CMTR1	ENSCAFP00000008061	ENSCAFP00000002124	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Cap methyltransferase 1.	0.480
POLR3F	RNF151	ENSCAFP00000008061	ENSCAFP00000028784	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Ring finger protein 151.	0.522
RNF122	RNF151	ENSCAFP00000009453	ENSCAFP00000028784	Ring finger protein 122.	Ring finger protein 151.	0.548
RNF122	RNF175	ENSCAFP00000009453	ENSCAFP00000050837	Ring finger protein 122.	Ring finger protein 175.	0.550
RNF126	RNF151	ENSCAFP00000066416	ENSCAFP00000028784	Uncharacterized protein.	Ring finger protein 151.	0.597
RNF126	RNF175	ENSCAFP00000066416	ENSCAFP00000050837	Uncharacterized protein.	Ring finger protein 175.	0.518
RNF151	BIRC6	ENSCAFP00000028784	ENSCAFP00000008679	Ring finger protein 151.	Baculoviral IAP repeat containing 6.	0.536
RNF151	CMTR1	ENSCAFP00000028784	ENSCAFP00000002124	Ring finger protein 151.	Cap methyltransferase 1.	0.522
RNF151	NSMCE1	ENSCAFP00000028784	ENSCAFP00000025739	Ring finger protein 151.	NSE1 homolog, SMC5-SMC6 complex component.	0.515
RNF151	PAMR1	ENSCAFP00000028784	ENSCAFP00000060491	Ring finger protein 151.	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	0.633
RNF151	POLR3F	ENSCAFP00000028784	ENSCAFP00000008061	Ring finger protein 151.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.522
RNF151	RNF122	ENSCAFP00000028784	ENSCAFP00000009453	Ring finger protein 151.	Ring finger protein 122.	0.548
RNF151	RNF126	ENSCAFP00000028784	ENSCAFP00000066416	Ring finger protein 151.	Uncharacterized protein.	0.597
RNF151	RNF175	ENSCAFP00000028784	ENSCAFP00000050837	Ring finger protein 151.	Ring finger protein 175.	0.670
RNF151	SPATA19	ENSCAFP00000028784	ENSCAFP00000014441	Ring finger protein 151.	Spermatogenesis associated 19.	0.515

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.792

expected number of edges:

10

PPI enrichment p-value:

3.85e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009166

Nucleotide catabolic process

7 of 52

2.39

5.76

1.11e-12

GO:0046496

Nicotinamide nucleotide metabolic process

5 of 24

2.58

4.57

1.57e-09

GO:0009394

2-deoxyribonucleotide metabolic process

5 of 27

2.53

4.46

2.24e-09

GO:0009125

Nucleoside monophosphate catabolic process

4 of 13

2.75

3.89

5.34e-08

GO:0009117

Nucleotide metabolic process

11 of 461

1.64

3.81

1.10e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008253

5-nucleotidase activity

5 of 13

2.85

5.01

4.22e-10

GO:0106411

XMP 5-nucleosidase activity

3 of 5

3.04

2.84

6.71e-06

GO:0050484

GMP 5-nucleotidase activity

2 of 2

3.26

1.75

0.00069

GO:0050146

Nucleoside phosphotransferase activity

2 of 2

3.26

1.75

0.00069

GO:0050483

IMP 5-nucleotidase activity

2 of 3

3.09

1.71

0.00081

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7146

Mixed, incl. Purine metabolism, and Nicotinate and nicotinamide metabolism

11 of 169

2.08

6.98

9.26e-20

CL:7147

Purine metabolism, and Nicotinate and nicotinamide metabolism

10 of 140

2.12

6.72

6.15e-18

CL:7238

Mixed, incl. 5-nucleotidase activity, and Purine salvage

6 of 22

2.7

6.06

2.07e-12

CL:7239

5-nucleotidase activity, and Adenosine deaminase

5 of 15

2.79

5.19

1.64e-10

CL:7379

Nicotinate and nicotinamide metabolism

4 of 19

2.59

3.57

1.72e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa00760

Nicotinate and nicotinamide metabolism

10 of 33

2.75

11.59

2.24e-24

cfa00240

Pyrimidine metabolism

5 of 42

2.34

4.23

2.76e-09

cfa00230

Purine metabolism

5 of 111

1.92

2.94

2.13e-07

cfa01100

Metabolic pathways

10 of 1220

1.18

1.69

1.16e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-196807

Nicotinate metabolism

6 of 25

2.64

5.79

5.73e-12

CFA-8956319

Nucleotide catabolism

4 of 31

2.37

3.09

9.87e-07

CFA-74259

Purine catabolism

3 of 16

2.54

2.42

3.02e-05

CFA-73621

Pyrimidine catabolism

2 of 8

2.66

1.44

0.0024

CFA-197264

Nicotinamide salvaging

2 of 14

2.42

1.22

0.0057

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0662

Pyridine nucleotide biosynthesis

2 of 7

2.72

1.32

0.0040

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06941

5 nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)

2 of 2

3.26

1.35

0.0037

PF05761

5 nucleotidase family

2 of 5

2.87

1.21

0.0065

PF00293

NUDIX domain

2 of 17

2.33

0.79

0.0351

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