node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTNNB1 | MYOD1 | ENSCAFP00000007783 | ENSCAFP00000013332 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | 0.463 |
CTNNB1 | TCF3 | ENSCAFP00000007783 | ENSCAFP00000028831 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Transcription factor 3. | 0.651 |
ID1 | ID3 | ENSCAFP00000010470 | ENSCAFP00000019544 | Inhibitor of DNA binding 1, HLH protein. | DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the [...] | 0.942 |
ID1 | ID4 | ENSCAFP00000010470 | ENSCAFP00000014976 | Inhibitor of DNA binding 1, HLH protein. | Inhibitor of DNA binding 4, HLH protein. | 0.930 |
ID1 | MYF5 | ENSCAFP00000010470 | ENSCAFP00000008695 | Inhibitor of DNA binding 1, HLH protein. | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | 0.523 |
ID1 | MYOD1 | ENSCAFP00000010470 | ENSCAFP00000013332 | Inhibitor of DNA binding 1, HLH protein. | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | 0.693 |
ID1 | TCF3 | ENSCAFP00000010470 | ENSCAFP00000028831 | Inhibitor of DNA binding 1, HLH protein. | Transcription factor 3. | 0.986 |
ID3 | ID1 | ENSCAFP00000019544 | ENSCAFP00000010470 | DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the [...] | Inhibitor of DNA binding 1, HLH protein. | 0.942 |
ID3 | ID4 | ENSCAFP00000019544 | ENSCAFP00000014976 | DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the [...] | Inhibitor of DNA binding 4, HLH protein. | 0.927 |
ID3 | TCF3 | ENSCAFP00000019544 | ENSCAFP00000028831 | DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the [...] | Transcription factor 3. | 0.691 |
ID4 | ID1 | ENSCAFP00000014976 | ENSCAFP00000010470 | Inhibitor of DNA binding 4, HLH protein. | Inhibitor of DNA binding 1, HLH protein. | 0.930 |
ID4 | ID3 | ENSCAFP00000014976 | ENSCAFP00000019544 | Inhibitor of DNA binding 4, HLH protein. | DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the [...] | 0.927 |
ID4 | MYOG | ENSCAFP00000014976 | ENSCAFP00000015142 | Inhibitor of DNA binding 4, HLH protein. | Myogenin. | 0.630 |
ID4 | TCF3 | ENSCAFP00000014976 | ENSCAFP00000028831 | Inhibitor of DNA binding 4, HLH protein. | Transcription factor 3. | 0.684 |
LMO2 | TAL1 | ENSCAFP00000010588 | ENSCAFP00000005977 | LIM domain only 2. | TAL bHLH transcription factor 1, erythroid differentiation factor. | 0.992 |
LMO2 | TCF3 | ENSCAFP00000010588 | ENSCAFP00000028831 | LIM domain only 2. | Transcription factor 3. | 0.682 |
MYF5 | ID1 | ENSCAFP00000008695 | ENSCAFP00000010470 | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | Inhibitor of DNA binding 1, HLH protein. | 0.523 |
MYF5 | MYF6 | ENSCAFP00000008695 | ENSCAFP00000008676 | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | Myogenic factor 6. | 0.690 |
MYF5 | MYOD1 | ENSCAFP00000008695 | ENSCAFP00000013332 | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | 0.422 |
MYF5 | MYOG | ENSCAFP00000008695 | ENSCAFP00000015142 | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | Myogenin. | 0.669 |