STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (739 aa)    
Predicted Functional Partners:
MBTPS1
Membrane bound transcription factor peptidase, site 1.
      
 0.742
GPR83
Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.650
PACS1
Phosphofurin acidic cluster sorting protein 1.
    
 
 0.643
SCG5
Secretogranin V.
   
 
 0.631
TFIP11
Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...]
   
  
 0.591
SLC38A3
Solute carrier family 38 member 3.
   
  
 0.575
EXOC3
Exocyst complex component 3.
      
 0.567
TOX
Thymocyte selection associated high mobility group box.
      
 0.560
EEA1
Early endosome antigen 1.
   
 
 0.551
CABIN1
Calcineurin binding protein 1.
   
 
 0.526
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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