STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FBXW5F-box and WD repeat domain containing 5. (802 aa)    
Predicted Functional Partners:
SKP1
S-phase kinase associated protein 1; Belongs to the SKP1 family.
    
 0.839
CUL1
Cullin 1; Belongs to the cullin family.
   
 0.833
POLR3F
Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.
    
 
 0.792
DDB1
Damage specific DNA binding protein 1.
   
 
 0.750
ENSCAFP00000049197
Uncharacterized protein; Belongs to the SKP1 family.
    
 
 0.743
ENSCAFP00000051783
Uncharacterized protein; Belongs to the SKP1 family.
    
 
 0.743
ENSCAFP00000063226
Uncharacterized protein; Belongs to the SKP1 family.
    
 
 0.743
FBXO25
F-box protein 25.
      
 0.722
SEC23A
Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.
    
 
 0.699
RBX1
Ring-box 1.
    
 0.639
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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