TRAF2 protein (Canis lupus familiaris) - STRING interaction network

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Score

TRAF2

TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)

Predicted Functional Partners:

TRADD

0.999

RIPK1

0.987

TNFRSF1A

0.979

IKBKB

0.973

IKBKG

0.970

MAP3K5

0.969

CHUK

0.969

TRAF3

0.968

BIRC3

0.967

BIRC2

0.965

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC2	BIRC3	ENSCAFP00000022277	ENSCAFP00000050122	Baculoviral IAP repeat containing 2.	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	0.903
BIRC2	CHUK	ENSCAFP00000022277	ENSCAFP00000014093	Baculoviral IAP repeat containing 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.654
BIRC2	IKBKB	ENSCAFP00000022277	ENSCAFP00000048001	Baculoviral IAP repeat containing 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.652
BIRC2	IKBKG	ENSCAFP00000022277	ENSCAFP00000028998	Baculoviral IAP repeat containing 2.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.740
BIRC2	RIPK1	ENSCAFP00000022277	ENSCAFP00000013721	Baculoviral IAP repeat containing 2.	Receptor interacting serine/threonine kinase 1.	0.964
BIRC2	TNFRSF1A	ENSCAFP00000022277	ENSCAFP00000062480	Baculoviral IAP repeat containing 2.	TNF receptor superfamily member 1A.	0.974
BIRC2	TRADD	ENSCAFP00000022277	ENSCAFP00000030230	Baculoviral IAP repeat containing 2.	TNFRSF1A associated via death domain.	0.952
BIRC2	TRAF2	ENSCAFP00000022277	ENSCAFP00000028895	Baculoviral IAP repeat containing 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.965
BIRC2	TRAF3	ENSCAFP00000022277	ENSCAFP00000026713	Baculoviral IAP repeat containing 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.973
BIRC3	BIRC2	ENSCAFP00000050122	ENSCAFP00000022277	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Baculoviral IAP repeat containing 2.	0.903
BIRC3	CHUK	ENSCAFP00000050122	ENSCAFP00000014093	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Component of inhibitor of nuclear factor kappa B kinase complex.	0.638
BIRC3	IKBKB	ENSCAFP00000050122	ENSCAFP00000048001	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.656
BIRC3	IKBKG	ENSCAFP00000050122	ENSCAFP00000028998	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.740
BIRC3	RIPK1	ENSCAFP00000050122	ENSCAFP00000013721	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Receptor interacting serine/threonine kinase 1.	0.964
BIRC3	TNFRSF1A	ENSCAFP00000050122	ENSCAFP00000062480	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	TNF receptor superfamily member 1A.	0.982
BIRC3	TRADD	ENSCAFP00000050122	ENSCAFP00000030230	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	TNFRSF1A associated via death domain.	0.952
BIRC3	TRAF2	ENSCAFP00000050122	ENSCAFP00000028895	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.967
BIRC3	TRAF3	ENSCAFP00000050122	ENSCAFP00000026713	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.969
CHUK	BIRC2	ENSCAFP00000014093	ENSCAFP00000022277	Component of inhibitor of nuclear factor kappa B kinase complex.	Baculoviral IAP repeat containing 2.	0.654
CHUK	BIRC3	ENSCAFP00000014093	ENSCAFP00000050122	Component of inhibitor of nuclear factor kappa B kinase complex.	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	0.638