STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFRSF25TNF receptor superfamily member 25. (469 aa)    
Predicted Functional Partners:
TNFSF15
TNF superfamily member 15.
    
 0.962
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
   
 
 0.739
TNFSF9
TNF superfamily member 9; Belongs to the tumor necrosis factor family.
   
  
 0.733
FCGRT
Fc fragment of IgG receptor and transporter; Belongs to the MHC class I family.
  
  
 0.718
TRADD
TNFRSF1A associated via death domain.
    
 
 0.717
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 
 0.618
TRAF4
TNF receptor associated factor 4.
    
 
 0.611
TNFSF8
Tumor necrosis factor ligand 3A; Belongs to the tumor necrosis factor family.
   
  
 0.610
P2RY6
Pyrimidinergic receptor P2Y6.
      
 0.608
TNFSF10
Tumor necrosis factor ligand superfamily member.
      
 0.598
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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