STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERRFI1ERBB receptor feedback inhibitor 1. (453 aa)    
Predicted Functional Partners:
EGFR
Receptor protein-tyrosine kinase.
   
 
 0.945
ERBB2
Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]
   
 
 0.604
ARL6IP5
PRA1 family protein.
   
  
 0.572
TAOK3
TAO kinase 3.
   
  
 0.565
MANEA
Mannosidase endo-alpha.
      
 0.564
ZBTB8A
Zinc finger and BTB domain containing 8A.
   
  
 0.562
CCNI
Cyclin I; Belongs to the cyclin family.
      
 0.561
BLVRB
Biliverdin reductase B.
      
 0.560
GRB2
Growth factor receptor bound protein 2.
   
 
 0.544
PAK1IP1
PAK1 interacting protein 1.
   
  
 0.524
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.