SHC2 protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

SHC2

Uncharacterized protein. (636 aa)

Predicted Functional Partners:

ERBB3

0.952

EGFR

0.950

ERBB4

0.948

ERBB2

0.947

GRB2

0.943

INSR

0.933

IGF1R

0.933

SOS2

0.930

MET

0.928

NTRK2

0.928

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSCAFP00000005164	ENSCAFP00000024079	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.997
EGFR	ERBB3	ENSCAFP00000005164	ENSCAFP00000000139	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.979
EGFR	ERBB4	ENSCAFP00000005164	ENSCAFP00000048210	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.888
EGFR	GRB2	ENSCAFP00000005164	ENSCAFP00000049390	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
EGFR	IGF1R	ENSCAFP00000005164	ENSCAFP00000043796	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.676
EGFR	INSR	ENSCAFP00000005164	ENSCAFP00000038176	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.570
EGFR	MET	ENSCAFP00000005164	ENSCAFP00000041478	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.786
EGFR	NTRK2	ENSCAFP00000005164	ENSCAFP00000063233	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.485
EGFR	SHC2	ENSCAFP00000005164	ENSCAFP00000029189	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.950
EGFR	SOS2	ENSCAFP00000005164	ENSCAFP00000021080	Receptor protein-tyrosine kinase.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.977
ERBB2	EGFR	ENSCAFP00000024079	ENSCAFP00000005164	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Receptor protein-tyrosine kinase.	0.997
ERBB2	ERBB3	ENSCAFP00000024079	ENSCAFP00000000139	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Erb-b2 receptor tyrosine kinase 3.	0.998
ERBB2	ERBB4	ENSCAFP00000024079	ENSCAFP00000048210	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Receptor protein-tyrosine kinase.	0.991
ERBB2	GRB2	ENSCAFP00000024079	ENSCAFP00000049390	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Growth factor receptor bound protein 2.	0.991
ERBB2	IGF1R	ENSCAFP00000024079	ENSCAFP00000043796	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase receptor.	0.793
ERBB2	INSR	ENSCAFP00000024079	ENSCAFP00000038176	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase receptor.	0.404
ERBB2	MET	ENSCAFP00000024079	ENSCAFP00000041478	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.561
ERBB2	NTRK2	ENSCAFP00000024079	ENSCAFP00000063233	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Tyrosine-protein kinase receptor.	0.442
ERBB2	SHC2	ENSCAFP00000024079	ENSCAFP00000029189	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Uncharacterized protein.	0.947
ERBB2	SOS2	ENSCAFP00000024079	ENSCAFP00000021080	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.534