STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF166Ring finger protein 166. (366 aa)    
Predicted Functional Partners:
KLHL28
Kelch like family member 28.
    
 
 0.923
ZNF653
Zinc finger protein 653.
   
 
 0.815
ZNF692
Zinc finger protein 692.
   
 
 0.796
ZNF827
Zinc finger protein 827.
   
 
 0.778
CORO7
Coronin; Belongs to the WD repeat coronin family.
   
  
 0.774
UBE2W
UBIQUITIN_CONJUGAT_2 domain-containing protein.
    
 
 0.710
LRSAM1
Leucine rich repeat and sterile alpha motif containing 1.
   
 
 0.707
CNTF
Uncharacterized protein.
   
 
 0.690
KLHL20
Kelch like family member 20.
   
 
 0.680
MED13L
Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
   
  
 0.679
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.