FOXF1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

FOXF1

Forkhead box F1. (354 aa)

Predicted Functional Partners:

BASP1

0.670

PAX1

0.642

CA12

0.604

MYOCD

0.591

SRF

0.527

GLI2

0.516

HOXB5

0.506

FOXL1

0.503

GLI3

0.487

EMC8

0.484

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BASP1	FOXF1	ENSCAFP00000042787	ENSCAFP00000029503	Brain abundant membrane attached signal protein 1.	Forkhead box F1.	0.670
CA12	FOXF1	ENSCAFP00000057765	ENSCAFP00000029503	Carbonic anhydrase 12; Belongs to the alpha-carbonic anhydrase family.	Forkhead box F1.	0.604
CA12	PAX1	ENSCAFP00000057765	ENSCAFP00000007720	Carbonic anhydrase 12; Belongs to the alpha-carbonic anhydrase family.	Paired box 1.	0.609
EMC8	FOXF1	ENSCAFP00000055747	ENSCAFP00000029503	ER membrane protein complex subunit 8.	Forkhead box F1.	0.484
FOXF1	BASP1	ENSCAFP00000029503	ENSCAFP00000042787	Forkhead box F1.	Brain abundant membrane attached signal protein 1.	0.670
FOXF1	CA12	ENSCAFP00000029503	ENSCAFP00000057765	Forkhead box F1.	Carbonic anhydrase 12; Belongs to the alpha-carbonic anhydrase family.	0.604
FOXF1	EMC8	ENSCAFP00000029503	ENSCAFP00000055747	Forkhead box F1.	ER membrane protein complex subunit 8.	0.484
FOXF1	FOXL1	ENSCAFP00000029503	ENSCAFP00000029496	Forkhead box F1.	Forkhead box L1.	0.503
FOXF1	GLI2	ENSCAFP00000029503	ENSCAFP00000007216	Forkhead box F1.	GLI family zinc finger 2.	0.516
FOXF1	GLI3	ENSCAFP00000029503	ENSCAFP00000005264	Forkhead box F1.	GLI family zinc finger 3.	0.487
FOXF1	HOXB5	ENSCAFP00000029503	ENSCAFP00000024781	Forkhead box F1.	Homeobox B5.	0.506
FOXF1	MYOCD	ENSCAFP00000029503	ENSCAFP00000026366	Forkhead box F1.	Myocardin.	0.591
FOXF1	PAX1	ENSCAFP00000029503	ENSCAFP00000007720	Forkhead box F1.	Paired box 1.	0.642
FOXF1	SRF	ENSCAFP00000029503	ENSCAFP00000002675	Forkhead box F1.	Serum response factor.	0.527
FOXL1	FOXF1	ENSCAFP00000029496	ENSCAFP00000029503	Forkhead box L1.	Forkhead box F1.	0.503
GLI2	FOXF1	ENSCAFP00000007216	ENSCAFP00000029503	GLI family zinc finger 2.	Forkhead box F1.	0.516
GLI2	GLI3	ENSCAFP00000007216	ENSCAFP00000005264	GLI family zinc finger 2.	GLI family zinc finger 3.	0.919
GLI3	FOXF1	ENSCAFP00000005264	ENSCAFP00000029503	GLI family zinc finger 3.	Forkhead box F1.	0.487
GLI3	GLI2	ENSCAFP00000005264	ENSCAFP00000007216	GLI family zinc finger 3.	GLI family zinc finger 2.	0.919
HOXB5	FOXF1	ENSCAFP00000024781	ENSCAFP00000029503	Homeobox B5.	Forkhead box F1.	0.506

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.863

expected number of edges:

12

PPI enrichment p-value:

0.000464

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033108

Mitochondrial respiratory chain complex assembly

7 of 47

1.95

3.64

2.62e-09

GO:0033617

Mitochondrial cytochrome c oxidase assembly

5 of 29

2.01

2.69

2.00e-06

GO:0007005

Mitochondrion organization

9 of 274

1.29

1.84

5.45e-08

GO:0065003

Protein-containing complex assembly

8 of 488

0.99

0.95

0.00011

GO:0016043

Cellular component organization

10 of 1889

0.5

0.35

0.0153

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005507

Copper ion binding

4 of 22

2.04

1.91

0.00015

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

9 of 69

1.89

4.65

1.55e-13

GO:0005740

Mitochondrial envelope

10 of 466

1.11

1.46

1.23e-08

GO:0005743

Mitochondrial inner membrane

5 of 269

1.05

0.78

0.0042

GO:0031966

Mitochondrial membrane

6 of 422

0.93

0.72

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33498264

(2021) Regulation of COX Assembly and Function by Twin CX9C Proteins-Implications for Human Disease.

6 of 16

2.35

3.81

2.66e-08

PMID:18761382

(2009) Redox regulation of protein folding in the mitochondrial intermembrane space.

6 of 34

2.02

2.89

6.77e-07

PMID:28886682

(2017) Copper Acquisition and Utilization in Fungi.

6 of 36

2.0

2.86

6.77e-07

PMID:34557489

(2021) Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells.

6 of 47

1.88

2.56

2.01e-06

PMID:29495437

(2018) The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants.

5 of 25

2.08

2.44

1.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2974

Respiratory chain complex IV assembly, and Heme a metabolic process

9 of 18

2.48

8.1

5.75e-18

CL:2995

Mixed, incl. CHCH domain, and Cytochrome c oxidase biogenesis protein Cmc1 like

4 of 6

2.6

3.49

2.57e-07

CL:2977

Copper chaperone activity, and Cytochrome oxidase c subunit VIb

3 of 5

2.56

2.32

4.72e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005758

Mitochondrial intermembrane space

8 of 59

1.91

4.21

1.45e-11

GOCC:1902695

Metallochaperone complex

3 of 4

2.65

2.52

2.12e-05

GOCC:0005740

Mitochondrial envelope

9 of 368

1.17

1.52

1.20e-07

GOCC:0005739

Mitochondrion

10 of 851

0.85

0.87

2.70e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

8 of 97

1.69

3.31

1.73e-10

KW-0186

Copper

4 of 27

1.95

2.29

1.50e-05

KW-0496

Mitochondrion

10 of 807

0.87

0.91

1.36e-06

KW-0999

Mitochondrion inner membrane

4 of 213

1.05

0.6

0.0273

KW-0143

Chaperone

3 of 105

1.23

0.6

0.0448

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08583

Cytochrome c oxidase biogenesis protein Cmc1 like

2 of 2

2.78

1.06

0.0120

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013892

Cytochrome c oxidase biogenesis protein Cmc1-like

2 of 2

2.78

0.78

0.0390

IPR009069

Cysteine alpha-hairpin motif superfamily

2 of 3

2.6

0.78

0.0390

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