CRISPLD2 protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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CRISPLD2

Cysteine rich secretory protein LCCL domain containing 2. (495 aa)

Predicted Functional Partners:

LOC100856570

0.784

LOC487740

0.784

TULP2

0.689

DPT

0.639

PDIA2

0.598

THBS4

0.590

ZBTB8A

0.565

PPCDC

0.552

KIAA0513

0.537

TSKU

0.524

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRISPLD2	DPT	ENSCAFP00000029542	ENSCAFP00000022484	Cysteine rich secretory protein LCCL domain containing 2.	Uncharacterized protein.	0.639
CRISPLD2	KIAA0513	ENSCAFP00000029542	ENSCAFP00000032372	Cysteine rich secretory protein LCCL domain containing 2.	KIAA0513.	0.537
CRISPLD2	LOC100856570	ENSCAFP00000029542	ENSCAFP00000013625	Cysteine rich secretory protein LCCL domain containing 2.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.784
CRISPLD2	LOC487740	ENSCAFP00000029542	ENSCAFP00000036914	Cysteine rich secretory protein LCCL domain containing 2.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.784
CRISPLD2	PDIA2	ENSCAFP00000029542	ENSCAFP00000057509	Cysteine rich secretory protein LCCL domain containing 2.	Protein disulfide isomerase family A member 2.	0.598
CRISPLD2	PPCDC	ENSCAFP00000029542	ENSCAFP00000045648	Cysteine rich secretory protein LCCL domain containing 2.	Phosphopantothenoylcysteine decarboxylase.	0.552
CRISPLD2	THBS4	ENSCAFP00000029542	ENSCAFP00000053810	Cysteine rich secretory protein LCCL domain containing 2.	Thrombospondin 4.	0.590
CRISPLD2	TSKU	ENSCAFP00000029542	ENSCAFP00000007776	Cysteine rich secretory protein LCCL domain containing 2.	Tsukushi, small leucine rich proteoglycan.	0.524
CRISPLD2	TULP2	ENSCAFP00000029542	ENSCAFP00000005775	Cysteine rich secretory protein LCCL domain containing 2.	Tubby like protein 2; Belongs to the TUB family.	0.689
CRISPLD2	ZBTB8A	ENSCAFP00000029542	ENSCAFP00000015381	Cysteine rich secretory protein LCCL domain containing 2.	Zinc finger and BTB domain containing 8A.	0.565
DPT	CRISPLD2	ENSCAFP00000022484	ENSCAFP00000029542	Uncharacterized protein.	Cysteine rich secretory protein LCCL domain containing 2.	0.639
DPT	THBS4	ENSCAFP00000022484	ENSCAFP00000053810	Uncharacterized protein.	Thrombospondin 4.	0.428
KIAA0513	CRISPLD2	ENSCAFP00000032372	ENSCAFP00000029542	KIAA0513.	Cysteine rich secretory protein LCCL domain containing 2.	0.537
LOC100856570	CRISPLD2	ENSCAFP00000013625	ENSCAFP00000029542	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Cysteine rich secretory protein LCCL domain containing 2.	0.784
LOC100856570	LOC487740	ENSCAFP00000013625	ENSCAFP00000036914	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.995
LOC487740	CRISPLD2	ENSCAFP00000036914	ENSCAFP00000029542	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Cysteine rich secretory protein LCCL domain containing 2.	0.784
LOC487740	LOC100856570	ENSCAFP00000036914	ENSCAFP00000013625	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.995
PDIA2	CRISPLD2	ENSCAFP00000057509	ENSCAFP00000029542	Protein disulfide isomerase family A member 2.	Cysteine rich secretory protein LCCL domain containing 2.	0.598
PDIA2	PPCDC	ENSCAFP00000057509	ENSCAFP00000045648	Protein disulfide isomerase family A member 2.	Phosphopantothenoylcysteine decarboxylase.	0.741
PPCDC	CRISPLD2	ENSCAFP00000045648	ENSCAFP00000029542	Phosphopantothenoylcysteine decarboxylase.	Cysteine rich secretory protein LCCL domain containing 2.	0.552

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.888

expected number of edges:

11

PPI enrichment p-value:

1.06e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032511

Late endosome to vacuole transport via multivesicular body sorting pathway

3 of 13

2.54

1.61

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30572

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and HCN channels

9 of 30

2.66

9.23

1.61e-19

CL:30574

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and Polypeptide N-acetylgalactosaminyltransferase activity

8 of 18

2.83

9.07

2.19e-18

CL:30577

Mixed, incl. Synaptonemal complex protein 2-like, and Rab-GTPase-TBC domain

5 of 6

3.1

5.88

1.49e-11

CL:30595

Vps55/LEPROT, and Uncharacterised protein family UPF0220

3 of 5

2.96

2.81

7.42e-06

CL:19564

Dystrophin-associated glycoprotein complex, and EF-hand

2 of 14

2.33

0.87

0.0251

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016012

Sarcoglycan complex

2 of 5

2.78

1.04

0.0129

GOCC:0005927

Muscle tendon junction

2 of 6

2.7

1.04

0.0129

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05255

Uncharacterised protein family (UPF0220)

2 of 2

3.18

1.3

0.0046

PF04790

Sarcoglycan complex subunit protein

2 of 5

2.78

1.15

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007919

Uncharacterised protein family UPF0220

2 of 2

3.18

1.02

0.0145

IPR039972

Sarcoglycan gamma/delta/zeta

2 of 4

2.88

0.97

0.0181

IPR006875

Sarcoglycan complex subunit protein

2 of 5

2.78

0.96

0.0181

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