STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (858 aa)    
Predicted Functional Partners:
LRRC8A
Leucine rich repeat containing 8 VRAC subunit A.
  
 
0.915
ADGRL2
Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.
    
   0.676
ADGRL1
Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.
    
   0.676
ADGRL3
Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.
    
   0.676
CLNS1A
Methylosome subunit pICln; Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm comple [...]
   
  
 0.641
LRRC8B
Leucine rich repeat containing 8 VRAC subunit B.
  
 
0.633
SLC12A6
Solute carrier family 12 member 6.
      
 0.599
BEST1
Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.
   
  
 0.591
BEST3
Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.
      
 0.586
BEST4
Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.
      
 0.579
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.