STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (264 aa)    
Predicted Functional Partners:
LOC478196
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
  
0.926
CEL
Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family.
   
 
 0.906
LOC479649
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
  
0.847
PPP1CA
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...]
    
 
 0.809
CTRB2
Chymotrypsin 2 chain A; Belongs to the peptidase S1 family.
  
  
0.796
CLPS
Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
   
  
 0.718
LOC475521
Cationic trypsin.
  
 
0.718
ACE2
Angiotensin-converting enzyme.
   
 
 0.680
TMPRSS2
Uncharacterized protein.
 
 
 
 0.668
LOC478220
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
  
0.665
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.