STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RPE65Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...] (533 aa)    
Predicted Functional Partners:
RDH5
Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.978
LRAT
Lecithin retinol acyltransferase.
   
 
 0.958
RDH10
Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.957
RDH11
Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.953
DGAT1
Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.
   
 
 0.923
PNPLA4
Patatin like phospholipase domain containing 4.
     
 0.910
AWAT2
Acyl-CoA wax alcohol acyltransferase 2.
   
 
 0.904
MERTK
MER proto-oncogene, tyrosine kinase.
   
  
 0.857
ABCA4
ATP binding cassette subfamily A member 4.
   
  
 0.843
BEST1
Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.
   
  
 0.840
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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