| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCA4 | CEP290 | ENSCAFP00000004971 | ENSCAFP00000054723 | ATP binding cassette subfamily A member 4. | Centrosomal protein 290. | 0.797 |
| ABCA4 | CNGB3 | ENSCAFP00000004971 | ENSCAFP00000013075 | ATP binding cassette subfamily A member 4. | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...] | 0.802 |
| ABCA4 | PDE6A | ENSCAFP00000004971 | ENSCAFP00000026963 | ATP binding cassette subfamily A member 4. | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; This protein participates in processes of transmission and amplification of the visual signal. | 0.629 |
| ABCA4 | RDH11 | ENSCAFP00000004971 | ENSCAFP00000064481 | ATP binding cassette subfamily A member 4. | Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.625 |
| ABCA4 | RDH12 | ENSCAFP00000004971 | ENSCAFP00000024199 | ATP binding cassette subfamily A member 4. | Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.577 |
| ABCA4 | RPE65 | ENSCAFP00000004971 | ENSCAFP00000030301 | ATP binding cassette subfamily A member 4. | Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...] | 0.856 |
| CEP290 | ABCA4 | ENSCAFP00000054723 | ENSCAFP00000004971 | Centrosomal protein 290. | ATP binding cassette subfamily A member 4. | 0.797 |
| CEP290 | CNGB3 | ENSCAFP00000054723 | ENSCAFP00000013075 | Centrosomal protein 290. | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...] | 0.537 |
| CEP290 | RDH12 | ENSCAFP00000054723 | ENSCAFP00000024199 | Centrosomal protein 290. | Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.828 |
| CEP290 | RPE65 | ENSCAFP00000054723 | ENSCAFP00000030301 | Centrosomal protein 290. | Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...] | 0.851 |
| CNGB3 | ABCA4 | ENSCAFP00000013075 | ENSCAFP00000004971 | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...] | ATP binding cassette subfamily A member 4. | 0.802 |
| CNGB3 | CEP290 | ENSCAFP00000013075 | ENSCAFP00000054723 | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...] | Centrosomal protein 290. | 0.537 |
| CNGB3 | PDE6A | ENSCAFP00000013075 | ENSCAFP00000026963 | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...] | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; This protein participates in processes of transmission and amplification of the visual signal. | 0.850 |
| CNGB3 | RPE65 | ENSCAFP00000013075 | ENSCAFP00000030301 | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...] | Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...] | 0.830 |
| DGAT1 | LRAT | ENSCAFP00000046404 | ENSCAFP00000036665 | Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. | Lecithin retinol acyltransferase. | 0.812 |
| DGAT1 | RDH10 | ENSCAFP00000046404 | ENSCAFP00000059818 | Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. | Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.931 |
| DGAT1 | RDH11 | ENSCAFP00000046404 | ENSCAFP00000064481 | Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. | Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.926 |
| DGAT1 | RDH12 | ENSCAFP00000046404 | ENSCAFP00000024199 | Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. | Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.939 |
| DGAT1 | RDH5 | ENSCAFP00000046404 | ENSCAFP00000000084 | Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. | Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.901 |
| DGAT1 | RPE65 | ENSCAFP00000046404 | ENSCAFP00000030301 | Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. | Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...] | 0.831 |
