STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (539 aa)    
Predicted Functional Partners:
FOSB
Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity.
   
 
 0.998
FOS
Fos proto-oncogene, AP-1 transcription factor subunit.
   
 0.987
FOSL2
FOS like 2, AP-1 transcription factor subunit.
   
 0.983
FOSL1
FOS like 1, AP-1 transcription factor subunit.
   
 0.975
JUNB
JunB proto-oncogene, AP-1 transcription factor subunit.
   
0.965
MAPK10
Mitogen-activated protein kinase.
    
 0.964
MAPK8
Mitogen-activated protein kinase.
    
 0.964
MAPK9
Mitogen-activated protein kinase.
    
 0.963
MEN1
Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...]
    
 
 0.939
NACA
Nascent polypeptide associated complex subunit alpha 2.
    
 0.816
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.