node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ELN | ENSCAFP00000065577 | ENSCAFP00000037359 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Elastin. | 0.721 |
ACAN | MMP12 | ENSCAFP00000065577 | ENSCAFP00000031802 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ZnMc domain-containing protein. | 0.628 |
ACAN | TIMP1 | ENSCAFP00000065577 | ENSCAFP00000062428 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Metalloproteinase inhibitor 1. | 0.434 |
ACAN | TIMP2 | ENSCAFP00000065577 | ENSCAFP00000035219 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. | 0.487 |
ACAN | TIMP3 | ENSCAFP00000065577 | ENSCAFP00000040576 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | TIMP metallopeptidase inhibitor 3. | 0.602 |
COL12A1 | MMP12 | ENSCAFP00000046331 | ENSCAFP00000031802 | Collagen type XII alpha 1 chain. | ZnMc domain-containing protein. | 0.793 |
ECSCR | ISCU | ENSCAFP00000041381 | ENSCAFP00000016673 | Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2 (By similarity). | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.680 |
ECSCR | MMP12 | ENSCAFP00000041381 | ENSCAFP00000031802 | Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2 (By similarity). | ZnMc domain-containing protein. | 0.697 |
ECSCR | TAF8 | ENSCAFP00000041381 | ENSCAFP00000002377 | Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2 (By similarity). | TATA-box binding protein associated factor 8. | 0.711 |
ECSCR | TMEM45A | ENSCAFP00000041381 | ENSCAFP00000049441 | Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2 (By similarity). | Transmembrane protein 45A. | 0.718 |
ELN | ACAN | ENSCAFP00000037359 | ENSCAFP00000065577 | Elastin. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.721 |
ELN | MMP12 | ENSCAFP00000037359 | ENSCAFP00000031802 | Elastin. | ZnMc domain-containing protein. | 0.626 |
ELN | TIMP2 | ENSCAFP00000037359 | ENSCAFP00000035219 | Elastin. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. | 0.400 |
ELN | TIMP3 | ENSCAFP00000037359 | ENSCAFP00000040576 | Elastin. | TIMP metallopeptidase inhibitor 3. | 0.407 |
ISCU | ECSCR | ENSCAFP00000016673 | ENSCAFP00000041381 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2 (By similarity). | 0.680 |
ISCU | MMP12 | ENSCAFP00000016673 | ENSCAFP00000031802 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | ZnMc domain-containing protein. | 0.606 |
ISCU | TAF8 | ENSCAFP00000016673 | ENSCAFP00000002377 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | TATA-box binding protein associated factor 8. | 0.737 |
ISCU | TMEM45A | ENSCAFP00000016673 | ENSCAFP00000049441 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Transmembrane protein 45A. | 0.787 |
MMP12 | ACAN | ENSCAFP00000031802 | ENSCAFP00000065577 | ZnMc domain-containing protein. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.628 |
MMP12 | COL12A1 | ENSCAFP00000031802 | ENSCAFP00000046331 | ZnMc domain-containing protein. | Collagen type XII alpha 1 chain. | 0.793 |