| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APIP | DUOXA1 | ENSCAFP00000043546 | ENSCAFP00000020192 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Dual oxidase maturation factor 1. | 0.518 |
| APIP | DUSP27 | ENSCAFP00000043546 | ENSCAFP00000022900 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.641 |
| APIP | RNF220 | ENSCAFP00000043546 | ENSCAFP00000031935 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Ring finger protein 220. | 0.749 |
| CARD8 | RNF220 | ENSCAFP00000053507 | ENSCAFP00000031935 | Uncharacterized protein. | Ring finger protein 220. | 0.613 |
| CCDC24 | ERI3 | ENSCAFP00000064238 | ENSCAFP00000047578 | Uncharacterized protein. | ERI1 exoribonuclease family member 3. | 0.881 |
| CCDC24 | PTPN9 | ENSCAFP00000064238 | ENSCAFP00000042090 | Uncharacterized protein. | SIN3 transcription regulator family member A. | 0.522 |
| CCDC24 | RNF220 | ENSCAFP00000064238 | ENSCAFP00000031935 | Uncharacterized protein. | Ring finger protein 220. | 0.928 |
| DUOXA1 | APIP | ENSCAFP00000020192 | ENSCAFP00000043546 | Dual oxidase maturation factor 1. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.518 |
| DUOXA1 | DUSP27 | ENSCAFP00000020192 | ENSCAFP00000022900 | Dual oxidase maturation factor 1. | Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.491 |
| DUOXA1 | RNF220 | ENSCAFP00000020192 | ENSCAFP00000031935 | Dual oxidase maturation factor 1. | Ring finger protein 220. | 0.591 |
| DUSP27 | APIP | ENSCAFP00000022900 | ENSCAFP00000043546 | Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.641 |
| DUSP27 | DUOXA1 | ENSCAFP00000022900 | ENSCAFP00000020192 | Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Dual oxidase maturation factor 1. | 0.491 |
| DUSP27 | RNF220 | ENSCAFP00000022900 | ENSCAFP00000031935 | Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Ring finger protein 220. | 0.697 |
| ERI3 | CCDC24 | ENSCAFP00000047578 | ENSCAFP00000064238 | ERI1 exoribonuclease family member 3. | Uncharacterized protein. | 0.881 |
| ERI3 | PTPN9 | ENSCAFP00000047578 | ENSCAFP00000042090 | ERI1 exoribonuclease family member 3. | SIN3 transcription regulator family member A. | 0.442 |
| ERI3 | RNF220 | ENSCAFP00000047578 | ENSCAFP00000031935 | ERI1 exoribonuclease family member 3. | Ring finger protein 220. | 0.741 |
| PTPN9 | CCDC24 | ENSCAFP00000042090 | ENSCAFP00000064238 | SIN3 transcription regulator family member A. | Uncharacterized protein. | 0.522 |
| PTPN9 | ERI3 | ENSCAFP00000042090 | ENSCAFP00000047578 | SIN3 transcription regulator family member A. | ERI1 exoribonuclease family member 3. | 0.442 |
| PTPN9 | RNF220 | ENSCAFP00000042090 | ENSCAFP00000031935 | SIN3 transcription regulator family member A. | Ring finger protein 220. | 0.604 |
| RNF220 | APIP | ENSCAFP00000031935 | ENSCAFP00000043546 | Ring finger protein 220. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.749 |
