node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRCA2 | LOC100687249 | ENSCAFP00000009557 | ENSCAFP00000032258 | BRCA2 DNA repair associated. | Cor1 domain-containing protein. | 0.912 |
BRCA2 | LOC102152531 | ENSCAFP00000009557 | ENSCAFP00000031959 | BRCA2 DNA repair associated. | Cor1 domain-containing protein. | 0.912 |
BRCA2 | MLH1 | ENSCAFP00000009557 | ENSCAFP00000007136 | BRCA2 DNA repair associated. | MutL homolog 1. | 0.690 |
BRCA2 | RAE1 | ENSCAFP00000009557 | ENSCAFP00000017710 | BRCA2 DNA repair associated. | SPO11 initiator of meiotic double stranded breaks. | 0.563 |
DAZL | HORMAD1 | ENSCAFP00000008780 | ENSCAFP00000017772 | Deleted in azoospermia like. | HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] | 0.615 |
DAZL | HORMAD2 | ENSCAFP00000008780 | ENSCAFP00000018347 | Deleted in azoospermia like. | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | 0.442 |
DAZL | LOC100687249 | ENSCAFP00000008780 | ENSCAFP00000032258 | Deleted in azoospermia like. | Cor1 domain-containing protein. | 0.767 |
DAZL | LOC102152531 | ENSCAFP00000008780 | ENSCAFP00000031959 | Deleted in azoospermia like. | Cor1 domain-containing protein. | 0.767 |
DAZL | RAE1 | ENSCAFP00000008780 | ENSCAFP00000017710 | Deleted in azoospermia like. | SPO11 initiator of meiotic double stranded breaks. | 0.649 |
HORMAD1 | DAZL | ENSCAFP00000017772 | ENSCAFP00000008780 | HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] | Deleted in azoospermia like. | 0.615 |
HORMAD1 | LOC100687249 | ENSCAFP00000017772 | ENSCAFP00000032258 | HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] | Cor1 domain-containing protein. | 0.756 |
HORMAD1 | LOC102152531 | ENSCAFP00000017772 | ENSCAFP00000031959 | HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] | Cor1 domain-containing protein. | 0.756 |
HORMAD1 | RAE1 | ENSCAFP00000017772 | ENSCAFP00000017710 | HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] | SPO11 initiator of meiotic double stranded breaks. | 0.958 |
HORMAD1 | SYCE1 | ENSCAFP00000017772 | ENSCAFP00000033815 | HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] | Synaptonemal complex central element protein 1. | 0.874 |
HORMAD1 | SYCE3 | ENSCAFP00000017772 | ENSCAFP00000041157 | HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] | Synaptonemal complex central element protein 3. | 0.828 |
HORMAD2 | DAZL | ENSCAFP00000018347 | ENSCAFP00000008780 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | Deleted in azoospermia like. | 0.442 |
HORMAD2 | LOC100687249 | ENSCAFP00000018347 | ENSCAFP00000032258 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | Cor1 domain-containing protein. | 0.763 |
HORMAD2 | LOC102152531 | ENSCAFP00000018347 | ENSCAFP00000031959 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | Cor1 domain-containing protein. | 0.763 |
HORMAD2 | RAE1 | ENSCAFP00000018347 | ENSCAFP00000017710 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | SPO11 initiator of meiotic double stranded breaks. | 0.778 |
HORMAD2 | SYCE1 | ENSCAFP00000018347 | ENSCAFP00000033815 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | Synaptonemal complex central element protein 1. | 0.629 |