| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BAX | BBC3 | ENSCAFP00000005763 | ENSCAFP00000054385 | BCL2 associated X, apoptosis regulator. | Uncharacterized protein. | 0.693 |
| BAX | BCL2 | ENSCAFP00000005763 | ENSCAFP00000000102 | BCL2 associated X, apoptosis regulator. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | 0.991 |
| BAX | BCL2L1 | ENSCAFP00000005763 | ENSCAFP00000010478 | BCL2 associated X, apoptosis regulator. | BCL2 like 1. | 0.987 |
| BAX | BCL2L11 | ENSCAFP00000005763 | ENSCAFP00000046855 | BCL2 associated X, apoptosis regulator. | BCL2 like 11. | 0.949 |
| BAX | BID | ENSCAFP00000005763 | ENSCAFP00000052515 | BCL2 associated X, apoptosis regulator. | BH3 interacting domain death agonist. | 0.989 |
| BAX | ENSCAFP00000045746 | ENSCAFP00000005763 | ENSCAFP00000045746 | BCL2 associated X, apoptosis regulator. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.899 |
| BAX | MCL1 | ENSCAFP00000005763 | ENSCAFP00000017738 | BCL2 associated X, apoptosis regulator. | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family. | 0.423 |
| BAX | PMAIP1 | ENSCAFP00000005763 | ENSCAFP00000032282 | BCL2 associated X, apoptosis regulator. | Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family. | 0.824 |
| BAX | TP53 | ENSCAFP00000005763 | ENSCAFP00000064590 | BCL2 associated X, apoptosis regulator. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.979 |
| BBC3 | BAX | ENSCAFP00000054385 | ENSCAFP00000005763 | Uncharacterized protein. | BCL2 associated X, apoptosis regulator. | 0.693 |
| BBC3 | BCL2 | ENSCAFP00000054385 | ENSCAFP00000000102 | Uncharacterized protein. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | 0.995 |
| BBC3 | BCL2A1 | ENSCAFP00000054385 | ENSCAFP00000053072 | Uncharacterized protein. | BCL2 related protein A1. | 0.837 |
| BBC3 | BCL2L1 | ENSCAFP00000054385 | ENSCAFP00000010478 | Uncharacterized protein. | BCL2 like 1. | 0.995 |
| BBC3 | BCL2L11 | ENSCAFP00000054385 | ENSCAFP00000046855 | Uncharacterized protein. | BCL2 like 11. | 0.940 |
| BBC3 | BID | ENSCAFP00000054385 | ENSCAFP00000052515 | Uncharacterized protein. | BH3 interacting domain death agonist. | 0.858 |
| BBC3 | ENSCAFP00000045746 | ENSCAFP00000054385 | ENSCAFP00000045746 | Uncharacterized protein. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.858 |
| BBC3 | MCL1 | ENSCAFP00000054385 | ENSCAFP00000017738 | Uncharacterized protein. | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family. | 0.970 |
| BBC3 | PMAIP1 | ENSCAFP00000054385 | ENSCAFP00000032282 | Uncharacterized protein. | Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family. | 0.970 |
| BBC3 | TP53 | ENSCAFP00000054385 | ENSCAFP00000064590 | Uncharacterized protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.920 |
| BCL2 | BAX | ENSCAFP00000000102 | ENSCAFP00000005763 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | BCL2 associated X, apoptosis regulator. | 0.991 |
