MAEL protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MAEL

Maelstrom spermatogenic transposon silencer. (469 aa)

Predicted Functional Partners:

MASTL

0.875

KIFC3

0.739

DDX4

0.592

IMPG1

0.575

ASZ1

0.574

TDRD9

0.566

ADAD1

0.558

DAZL

0.557

SYCE1

0.549

HORMAD1

0.547

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAD1	MAEL	ENSCAFP00000065730	ENSCAFP00000032345	Adenosine deaminase domain containing 1.	Maelstrom spermatogenic transposon silencer.	0.558
ASZ1	DDX4	ENSCAFP00000037886	ENSCAFP00000046169	Ankyrin repeat, SAM and basic leucine zipper domain containing 1.	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	0.468
ASZ1	MAEL	ENSCAFP00000037886	ENSCAFP00000032345	Ankyrin repeat, SAM and basic leucine zipper domain containing 1.	Maelstrom spermatogenic transposon silencer.	0.574
ASZ1	SYCE1	ENSCAFP00000037886	ENSCAFP00000033815	Ankyrin repeat, SAM and basic leucine zipper domain containing 1.	Synaptonemal complex central element protein 1.	0.565
ASZ1	TDRD9	ENSCAFP00000037886	ENSCAFP00000042172	Ankyrin repeat, SAM and basic leucine zipper domain containing 1.	Tudor domain containing 9.	0.476
DAZL	DDX4	ENSCAFP00000008780	ENSCAFP00000046169	Deleted in azoospermia like.	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	0.870
DAZL	HORMAD1	ENSCAFP00000008780	ENSCAFP00000017772	Deleted in azoospermia like.	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	0.615
DAZL	MAEL	ENSCAFP00000008780	ENSCAFP00000032345	Deleted in azoospermia like.	Maelstrom spermatogenic transposon silencer.	0.557
DDX4	ASZ1	ENSCAFP00000046169	ENSCAFP00000037886	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	Ankyrin repeat, SAM and basic leucine zipper domain containing 1.	0.468
DDX4	DAZL	ENSCAFP00000046169	ENSCAFP00000008780	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	Deleted in azoospermia like.	0.870
DDX4	HORMAD1	ENSCAFP00000046169	ENSCAFP00000017772	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	0.420
DDX4	MAEL	ENSCAFP00000046169	ENSCAFP00000032345	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	Maelstrom spermatogenic transposon silencer.	0.592
DDX4	TDRD9	ENSCAFP00000046169	ENSCAFP00000042172	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	Tudor domain containing 9.	0.419
HORMAD1	DAZL	ENSCAFP00000017772	ENSCAFP00000008780	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	Deleted in azoospermia like.	0.615
HORMAD1	DDX4	ENSCAFP00000017772	ENSCAFP00000046169	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	0.420
HORMAD1	MAEL	ENSCAFP00000017772	ENSCAFP00000032345	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	Maelstrom spermatogenic transposon silencer.	0.547
HORMAD1	SYCE1	ENSCAFP00000017772	ENSCAFP00000033815	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	Synaptonemal complex central element protein 1.	0.874
HORMAD1	TDRD9	ENSCAFP00000017772	ENSCAFP00000042172	HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]	Tudor domain containing 9.	0.418
IMPG1	KIFC3	ENSCAFP00000004093	ENSCAFP00000056671	Interphotoreceptor matrix proteoglycan 1.	Kinesin family member C3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.566
IMPG1	MAEL	ENSCAFP00000004093	ENSCAFP00000032345	Interphotoreceptor matrix proteoglycan 1.	Maelstrom spermatogenic transposon silencer.	0.575