STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H4C7Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)    
Predicted Functional Partners:
LOC111090006
Histone H3; Belongs to the histone H3 family.
 
 
 
 0.891
H3C13
Histone H3.
 
 
 
 0.889
LOC480110
Histone H3; Belongs to the histone H3 family.
 
 
 
 0.873
LOC612779
Histone H3; Belongs to the histone H3 family.
 
 
 
 0.863
LOC488263
Histone H3; Belongs to the histone H3 family.
 
 
 
 0.860
LOC482202
Histone H2B; Belongs to the histone H2B family.
 
 
 
 0.743
LOC488290
Histone H2B; Belongs to the histone H2B family.
 
 
 
 0.691
MACROH2A1
Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.
 
 
 
 0.687
NASP
Nuclear autoantigenic sperm protein.
    
 
 0.685
BRD4
Bromodomain containing 4.
    
 
 0.684
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.