STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHN2Chimaerin; GTPase-activating protein for p21-rac. (468 aa)    
Predicted Functional Partners:
MTUS1
Microtubule associated scaffold protein 1.
   
  
 0.675
COG1
Component of oligomeric golgi complex 1.
   
  
 0.632
CD6
CD6 molecule.
      
 0.600
NCAM2
Neural cell adhesion molecule 2.
   
  
 0.573
ARL5B
ADP ribosylation factor like GTPase 5B; Belongs to the small GTPase superfamily. Arf family.
   
 
 0.527
RAC1
Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]
    
 0.518
TMTC4
Transmembrane O-mannosyltransferase targeting cadherins 4.
      
 0.504
TOMM40
Translocase of outer mitochondrial membrane 40.
      
 0.501
PREX1
Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1.
    
 
 0.493
SPINK8
Serine peptidase inhibitor, Kazal type 8 (putative).
      
 0.483
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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