STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
E2RLH2_CANLFUncharacterized protein. (198 aa)    
Predicted Functional Partners:
ARHGDIA
Rho GDP dissociation inhibitor alpha.
   
 
 0.889
ITSN2
Intersectin 2.
    
 
 0.833
LOC100856635
Uncharacterized protein.
    
 
 0.763
ITSN1
Intersectin 1.
    
 
 0.763
ROCK1
Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
   
 
 0.635
ROCK2
Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
   
 
 0.627
ARHGDIB
Rho GDP dissociation inhibitor beta.
   
 
 0.614
PAK1
Non-specific serine/threonine protein kinase.
   
 
 0.608
PKN1
Protein kinase N1.
   
 
 0.596
ARHGAP35
Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...]
    
 
 0.573
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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