BNIP3 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	BCL2L1	ENSCAFP00000000102	ENSCAFP00000010478	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	BCL2 like 1.	0.995
BCL2	BNIP3	ENSCAFP00000000102	ENSCAFP00000033658	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	BCL2 interacting protein 3.	0.990
BCL2	PINK1	ENSCAFP00000000102	ENSCAFP00000057576	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	PTEN induced kinase 1.	0.727
BCL2	ULK1	ENSCAFP00000000102	ENSCAFP00000009679	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Unc-51 like autophagy activating kinase 1.	0.510
BCL2L1	BCL2	ENSCAFP00000010478	ENSCAFP00000000102	BCL2 like 1.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.995
BCL2L1	BNIP3	ENSCAFP00000010478	ENSCAFP00000033658	BCL2 like 1.	BCL2 interacting protein 3.	0.951
BCL2L1	PINK1	ENSCAFP00000010478	ENSCAFP00000057576	BCL2 like 1.	PTEN induced kinase 1.	0.962
BNIP3	BCL2	ENSCAFP00000033658	ENSCAFP00000000102	BCL2 interacting protein 3.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.990
BNIP3	BCL2L1	ENSCAFP00000033658	ENSCAFP00000010478	BCL2 interacting protein 3.	BCL2 like 1.	0.951
BNIP3	FUNDC1	ENSCAFP00000033658	ENSCAFP00000021402	BCL2 interacting protein 3.	FUN14 domain containing 1.	0.930
BNIP3	GABARAP	ENSCAFP00000033658	ENSCAFP00000023725	BCL2 interacting protein 3.	GABA type A receptor-associated protein.	0.925
BNIP3	GABARAPL1	ENSCAFP00000033658	ENSCAFP00000051867	BCL2 interacting protein 3.	GABA type A receptor associated protein like 1.	0.904
BNIP3	GABARAPL2	ENSCAFP00000033658	ENSCAFP00000039909	BCL2 interacting protein 3.	GABA type A receptor associated protein like 2.	0.925
BNIP3	PINK1	ENSCAFP00000033658	ENSCAFP00000057576	BCL2 interacting protein 3.	PTEN induced kinase 1.	0.944
BNIP3	RHEB	ENSCAFP00000033658	ENSCAFP00000050252	BCL2 interacting protein 3.	Ras homolog, mTORC1 binding.	0.968
BNIP3	RHEBL1	ENSCAFP00000033658	ENSCAFP00000065305	BCL2 interacting protein 3.	RHEB like 1.	0.908
BNIP3	ULK1	ENSCAFP00000033658	ENSCAFP00000009679	BCL2 interacting protein 3.	Unc-51 like autophagy activating kinase 1.	0.953
FUNDC1	BNIP3	ENSCAFP00000021402	ENSCAFP00000033658	FUN14 domain containing 1.	BCL2 interacting protein 3.	0.930
FUNDC1	GABARAP	ENSCAFP00000021402	ENSCAFP00000023725	FUN14 domain containing 1.	GABA type A receptor-associated protein.	0.889
FUNDC1	GABARAPL1	ENSCAFP00000021402	ENSCAFP00000051867	FUN14 domain containing 1.	GABA type A receptor associated protein like 1.	0.864