STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FIBPFGF1 intracellular binding protein. (357 aa)    
Predicted Functional Partners:
C2CD5
C2 calcium dependent domain containing 5.
    
 
 0.635
CDK5
Cyclin dependent kinase 5.
   
 
 0.586
CABLES1
Cdk5 and Abl enzyme substrate 1.
    
   0.580
ENSCAFP00000053140
Uncharacterized protein.
   
 
 0.580
TMEM94
Transmembrane protein 94.
    
   0.538
EFEMP2
EGF containing fibulin extracellular matrix protein 2.
 
 
  
 0.529
COPS6
COP9 signalosome subunit 6.
   
 
 0.494
KLK9
Kallikrein-related peptidase 9; Belongs to the peptidase S1 family.
    
 
 0.485
FGF1
Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]
   
 
 0.447
CABLES2
Cdk5 and Abl enzyme substrate 2.
    
   0.426
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.