FRZB protein (Canis lupus familiaris) - STRING interaction network

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Score

FRZB

Frizzled related protein. (168 aa)

Predicted Functional Partners:

WIF1

0.715

WNT6

0.675

DKK2

0.657

MATN3

0.651

SFRP2

0.617

CTNNB1

0.614

DKK4

0.606

DKK1

0.595

LRP5

0.584

IGFBP5

0.584

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	DKK1	ENSCAFP00000007783	ENSCAFP00000022864	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Dickkopf WNT signaling pathway inhibitor 1.	0.839
CTNNB1	DKK2	ENSCAFP00000007783	ENSCAFP00000016333	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Dickkopf WNT signaling pathway inhibitor 2.	0.709
CTNNB1	DKK4	ENSCAFP00000007783	ENSCAFP00000008237	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Dickkopf WNT signaling pathway inhibitor 4.	0.670
CTNNB1	FRZB	ENSCAFP00000007783	ENSCAFP00000034426	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Frizzled related protein.	0.614
CTNNB1	LRP5	ENSCAFP00000007783	ENSCAFP00000016050	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.903
CTNNB1	SFRP2	ENSCAFP00000007783	ENSCAFP00000012270	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.	0.646
CTNNB1	WIF1	ENSCAFP00000007783	ENSCAFP00000061273	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	WNT inhibitory factor 1.	0.698
CTNNB1	WNT6	ENSCAFP00000007783	ENSCAFP00000038712	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.658
DKK1	CTNNB1	ENSCAFP00000022864	ENSCAFP00000007783	Dickkopf WNT signaling pathway inhibitor 1.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.839
DKK1	DKK2	ENSCAFP00000022864	ENSCAFP00000016333	Dickkopf WNT signaling pathway inhibitor 1.	Dickkopf WNT signaling pathway inhibitor 2.	0.649
DKK1	DKK4	ENSCAFP00000022864	ENSCAFP00000008237	Dickkopf WNT signaling pathway inhibitor 1.	Dickkopf WNT signaling pathway inhibitor 4.	0.514
DKK1	FRZB	ENSCAFP00000022864	ENSCAFP00000034426	Dickkopf WNT signaling pathway inhibitor 1.	Frizzled related protein.	0.595
DKK1	LRP5	ENSCAFP00000022864	ENSCAFP00000016050	Dickkopf WNT signaling pathway inhibitor 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.999
DKK1	SFRP2	ENSCAFP00000022864	ENSCAFP00000012270	Dickkopf WNT signaling pathway inhibitor 1.	Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.	0.654
DKK1	WIF1	ENSCAFP00000022864	ENSCAFP00000061273	Dickkopf WNT signaling pathway inhibitor 1.	WNT inhibitory factor 1.	0.687
DKK1	WNT6	ENSCAFP00000022864	ENSCAFP00000038712	Dickkopf WNT signaling pathway inhibitor 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.462
DKK2	CTNNB1	ENSCAFP00000016333	ENSCAFP00000007783	Dickkopf WNT signaling pathway inhibitor 2.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.709
DKK2	DKK1	ENSCAFP00000016333	ENSCAFP00000022864	Dickkopf WNT signaling pathway inhibitor 2.	Dickkopf WNT signaling pathway inhibitor 1.	0.649
DKK2	DKK4	ENSCAFP00000016333	ENSCAFP00000008237	Dickkopf WNT signaling pathway inhibitor 2.	Dickkopf WNT signaling pathway inhibitor 4.	0.905
DKK2	FRZB	ENSCAFP00000016333	ENSCAFP00000034426	Dickkopf WNT signaling pathway inhibitor 2.	Frizzled related protein.	0.657