STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DENND4CDENN domain containing 4C. (1971 aa)    
Predicted Functional Partners:
MINDY1
MINDY lysine 48 deubiquitinase 1.
      
 0.738
RAB10
Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...]
   
 0.733
WHAMM
WASP homolog associated with actin, golgi membranes and microtubules.
      
 0.705
ANKFY1
Ankyrin repeat and FYVE domain containing 1.
   
  
 0.682
AVL9
AVL9 cell migration associated.
   
  
 0.647
DENND1A
DENN domain containing 1A.
   
 
0.598
AMN1
DENN domain containing 5B.
    
 
0.585
RIC1
RIC1 homolog, RAB6A GEF complex partner 1.
   
  
 0.567
VMP1
Vacuole membrane protein 1.
      
 0.564
DENND1C
DENN domain containing 1C.
    
 
0.554
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.