Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TIMP2Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (177 aa)    
Predicted Functional Partners:
MMP14
Matrix metallopeptidase 14.
   
 0.997
MMP9
Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).
   
 0.964
MMP15
Matrix metallopeptidase 15.
   
 0.948
MMP2
Matrix metallopeptidase 2.
   
 0.887
TIMP1
Metalloproteinase inhibitor 1.
   
 
 0.861
MMP13
Matrix metallopeptidase 13.
   
 0.837
MMP1
Matrix metallopeptidase 1.
   
 0.836
MMP17
Matrix metallopeptidase 17.
   
 0.832
MMP24
Matrix metallopeptidase 24.
   
 0.832
MMP16
Matrix metallopeptidase 16.
   
 0.832
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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