node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP1A2 | CYP1B1 | ENSCAFP00000059348 | ENSCAFP00000009250 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.955 |
CYP1A2 | CYP26A1 | ENSCAFP00000059348 | ENSCAFP00000011244 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.965 |
CYP1A2 | CYP2C18 | ENSCAFP00000059348 | ENSCAFP00000011937 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 2C21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Showed testosterone hydrolase activity. | 0.941 |
CYP1A2 | CYP3A12 | ENSCAFP00000059348 | ENSCAFP00000022005 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 3A12. | 0.955 |
CYP1A2 | CYP3A4 | ENSCAFP00000059348 | ENSCAFP00000021934 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 3A12; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.974 |
CYP1A2 | EPHX1 | ENSCAFP00000059348 | ENSCAFP00000050973 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.958 |
CYP1A2 | LOC100686607 | ENSCAFP00000059348 | ENSCAFP00000033797 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.961 |
CYP1A2 | LOC100856068 | ENSCAFP00000059348 | ENSCAFP00000035078 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.961 |
CYP1A2 | LOC480777 | ENSCAFP00000059348 | ENSCAFP00000033807 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | UDP-glucuronosyltransferase 2B31; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs. | 0.950 |
CYP1A2 | UGT1A6 | ENSCAFP00000059348 | ENSCAFP00000064520 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. | 0.975 |
CYP1B1 | CYP1A2 | ENSCAFP00000009250 | ENSCAFP00000059348 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.955 |
CYP1B1 | CYP2C18 | ENSCAFP00000009250 | ENSCAFP00000011937 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 2C21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Showed testosterone hydrolase activity. | 0.929 |
CYP1B1 | CYP3A12 | ENSCAFP00000009250 | ENSCAFP00000022005 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 3A12. | 0.488 |
CYP1B1 | CYP3A4 | ENSCAFP00000009250 | ENSCAFP00000021934 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 3A12; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.566 |
CYP1B1 | EPHX1 | ENSCAFP00000009250 | ENSCAFP00000050973 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.963 |
CYP1B1 | LOC100686607 | ENSCAFP00000009250 | ENSCAFP00000033797 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.928 |
CYP1B1 | LOC100856068 | ENSCAFP00000009250 | ENSCAFP00000035078 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.933 |
CYP1B1 | LOC480777 | ENSCAFP00000009250 | ENSCAFP00000033807 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase 2B31; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs. | 0.923 |
CYP1B1 | UGT1A6 | ENSCAFP00000009250 | ENSCAFP00000064520 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. | 0.956 |
CYP26A1 | CYP1A2 | ENSCAFP00000011244 | ENSCAFP00000059348 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.965 |