STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPP1Secreted phosphoprotein 1. (299 aa)    
Predicted Functional Partners:
CD44
CD44 antigen.
   
 0.999
MMP3
Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.
   
 
 0.876
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
   
 0.867
SPARC
Secreted protein acidic and cysteine rich.
   
  
 0.861
MMP7
Matrix metallopeptidase 7.
     
 0.814
BMP2
Bone morphogenetic protein 2.
   
  
 0.762
RUNX2
RUNX family transcription factor 2.
      
 0.712
ITGA9
Integrin subunit alpha 9; Belongs to the integrin alpha chain family.
   
 0.708
COL1A1
Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).
   
  
 0.703
FAM20C
FAM20C golgi associated secretory pathway kinase.
   
 0.681
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.