DOCK6 protein (Canis lupus familiaris) - STRING interaction network

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Score

DOCK6

Dedicator of cytokinesis 6; Belongs to the DOCK family. (2101 aa)

Predicted Functional Partners:

CDC42

0.777

DOCK2

0.710

LRCH3

0.708

RIMKLB

0.678

LRCH1

0.659

RAC1

0.596

CDC42-2

0.574

ZSWIM6

0.572

ZSWIM6-2

0.572

DOCK8

0.571

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	DOCK2	ENSCAFP00000021684	ENSCAFP00000024998	Cell division cycle 42.	Dedicator of cytokinesis 2; Belongs to the DOCK family.	0.716
CDC42	DOCK6	ENSCAFP00000021684	ENSCAFP00000035933	Cell division cycle 42.	Dedicator of cytokinesis 6; Belongs to the DOCK family.	0.777
CDC42	DOCK8	ENSCAFP00000021684	ENSCAFP00000060841	Cell division cycle 42.	Dedicator of cytokinesis 8; Belongs to the DOCK family.	0.868
CDC42	RAC1	ENSCAFP00000021684	ENSCAFP00000032062	Cell division cycle 42.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.765
CDC42-2	DOCK2	ENSCAFP00000060180	ENSCAFP00000024998	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Dedicator of cytokinesis 2; Belongs to the DOCK family.	0.546
CDC42-2	DOCK6	ENSCAFP00000060180	ENSCAFP00000035933	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Dedicator of cytokinesis 6; Belongs to the DOCK family.	0.574
CDC42-2	DOCK8	ENSCAFP00000060180	ENSCAFP00000060841	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Dedicator of cytokinesis 8; Belongs to the DOCK family.	0.785
DOCK2	CDC42	ENSCAFP00000024998	ENSCAFP00000021684	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Cell division cycle 42.	0.716
DOCK2	CDC42-2	ENSCAFP00000024998	ENSCAFP00000060180	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.546
DOCK2	DOCK6	ENSCAFP00000024998	ENSCAFP00000035933	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Dedicator of cytokinesis 6; Belongs to the DOCK family.	0.710
DOCK2	DOCK8	ENSCAFP00000024998	ENSCAFP00000060841	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Dedicator of cytokinesis 8; Belongs to the DOCK family.	0.746
DOCK2	RAC1	ENSCAFP00000024998	ENSCAFP00000032062	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.840
DOCK6	CDC42	ENSCAFP00000035933	ENSCAFP00000021684	Dedicator of cytokinesis 6; Belongs to the DOCK family.	Cell division cycle 42.	0.777
DOCK6	CDC42-2	ENSCAFP00000035933	ENSCAFP00000060180	Dedicator of cytokinesis 6; Belongs to the DOCK family.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.574
DOCK6	DOCK2	ENSCAFP00000035933	ENSCAFP00000024998	Dedicator of cytokinesis 6; Belongs to the DOCK family.	Dedicator of cytokinesis 2; Belongs to the DOCK family.	0.710
DOCK6	DOCK8	ENSCAFP00000035933	ENSCAFP00000060841	Dedicator of cytokinesis 6; Belongs to the DOCK family.	Dedicator of cytokinesis 8; Belongs to the DOCK family.	0.571
DOCK6	LRCH1	ENSCAFP00000035933	ENSCAFP00000006677	Dedicator of cytokinesis 6; Belongs to the DOCK family.	Leucine rich repeats and calponin homology domain containing 1.	0.659
DOCK6	LRCH3	ENSCAFP00000035933	ENSCAFP00000018733	Dedicator of cytokinesis 6; Belongs to the DOCK family.	Leucine rich repeats and calponin homology domain containing 3.	0.708
DOCK6	RAC1	ENSCAFP00000035933	ENSCAFP00000032062	Dedicator of cytokinesis 6; Belongs to the DOCK family.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.596
DOCK6	RIMKLB	ENSCAFP00000035933	ENSCAFP00000020456	Dedicator of cytokinesis 6; Belongs to the DOCK family.	Ribosomal modification protein rimK like family member B.	0.678