STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COL8A1Collagen type VIII alpha 1 chain. (744 aa)    
Predicted Functional Partners:
ENSCAFP00000064001
Endostatin domain-containing protein.
 
  
 
 0.862
COL8A2
Collagen type VIII alpha 2 chain.
  
0.856
PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2.
   
 0.730
COL21A1
Collagen type XXI alpha 1 chain.
  
0.709
POSTN
Periostin.
   
 
 0.678
COL1A2
Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family.
  
0.665
REN
Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
   
  
 0.654
COL15A1
Collagen type XV alpha 1 chain.
  
0.637
COL6A1
Collagen type VI alpha 1 chain.
  
0.636
COL4A1
Collagen type IV alpha 1 chain.
  
0.634
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.