STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DPH12-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (446 aa)    
Predicted Functional Partners:
DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.
   
0.994
DPH3
Diphthamide biosynthesis 3.
   
 0.993
DPH5
Diphthamide biosynthesis 5.
   
 0.984
EEF2
Eukaryotic translation elongation factor 2.
    
 0.836
DPH6
Diphthamine biosynthesis 6.
      
 0.827
DPH7
Diphthamide biosynthesis 7.
      
 0.802
OVCA2
OVCA2 serine hydrolase domain containing.
 
 
  
 0.687
PPP1R8
Protein phosphatase 1 regulatory subunit 8.
      
 0.677
ZBTB17
Zinc finger and BTB domain containing 17.
      
 0.673
DTYMK
Deoxythymidylate kinase.
      
 0.645
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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